Circ_0003945: an emerging biomarker and therapeutic target for human diseases

Front Oncol. 2024 Apr 22:14:1275009. doi: 10.3389/fonc.2024.1275009. eCollection 2024.


Due to the rapid development of RNA sequencing techniques, a circular non-coding RNA (ncRNA) known as circular RNAs (circRNAs) has gradually come into focus. As a distinguished member of the circRNA family, circ_0003945 has garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that circ_0003945 could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug resistance, and radio resistance through the molecular mechanism of competitive endogenous RNA (ceRNA) during tumorigenesis. The expression of circ_0003945 is frequently associated with some clinical parameters and implies a poorer prognosis in the majority of cancers. In non-malignant conditions, circ_0003945 also holds considerable importance in diseases pathogenesis. This review aims to recapitulate molecular mechanism of circ_0003945 and elucidates its potential as a diagnostic and therapeutic target in neoplasms and other diseases.

Keywords: biomarker; cancer; ceRNA; circ_0003945; therapeutic target.

Publication types

  • Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Natural Science Foundation of China (No.82072591, 81871871 to ZW), Jiangsu Province Capability Improvement Project through Science, Technology and Education; Jiangsu Provincial Medical Key Discipline Cultivation Unit (No. JSDW202235 to ZW), Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. SJCX23_0657 to LM), Bethune Medical Science Research Foundation Project (2022-YJ-085-J-Z-ZZ-006).