Tall-columnar glandular cells in SurePath™ liquid-based cytology Pap sample: Learning from mimics/pitfalls

Cytopathology. 2024 Jul;35(4):510-514. doi: 10.1111/cyt.13385. Epub 2024 May 7.

Abstract

We offer a comprehensive depiction of the cytomorphological characteristics of lobular endocervical glandular hyperplasia (LEGH) as observed in SurePath™ liquid-based cytology (LBC), subsequently confirmed on cone biopsy. Lobular endocervical glandular hyperplasia (LEGH), a precursor to gastric-type adenocarcinoma (GAE) of the endocervix, is rare and reports of it in cervical cytology are scarce. We provide a thorough description of the cytomorphological features of LEGH observed in SurePath™ liquid-based cytology (LBC), later confirmed by cone biopsy. To the best of our knowledge, this is the first report documenting cytology of LEGH in LBC of a Pap sample.

Keywords: Pap sample; gastric type adenocarcinoma endocervix; intestinal metaplasia; liquid‐based cytology; lobular endocervical glandular hyperplasia.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / pathology
  • Adult
  • Cervix Uteri* / pathology
  • Cytodiagnosis / methods
  • Female
  • Humans
  • Hyperplasia* / diagnosis
  • Hyperplasia* / pathology
  • Papanicolaou Test* / methods
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / pathology
  • Vaginal Smears* / methods