The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes

Cell. 1985 Feb;40(2):237-46. doi: 10.1016/0092-8674(85)90138-2.


The T cell surface glycoproteins T4 and T8 are thought to mediate efficient cell-cell interactions in the immune system and in this way may be responsible for the appropriate targeting of subpopulations of T cells. We have used gene transfer combined with subtractive hybridization to isolate both cDNA and functional genomic clones encoding the T8 protein. The sequence of the cDNA reveals that T8 is a transmembrane protein with an N-terminal domain which shares significant homology to immunoglobulin variable region light chains. This immunoglobulin-like structure is likely to be important in the function of T8 during differentiation and in the course of the immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / analysis
  • Base Sequence
  • DNA / isolation & purification
  • Genes*
  • Glycoproteins / genetics*
  • Glycoproteins / physiology
  • Humans
  • L Cells / immunology
  • Major Histocompatibility Complex
  • Mice
  • Nucleic Acid Hybridization
  • T-Lymphocytes / immunology*
  • Transformation, Genetic


  • Antigens
  • Glycoproteins
  • DNA

Associated data

  • GENBANK/M12828