Natural products with potential hypoglycemic activity in T2DM: 2019-2023

Phytochemistry. 2024 Jul:223:114130. doi: 10.1016/j.phytochem.2024.114130. Epub 2024 May 5.


As currently the most common metabolic disease, type 2 diabetes mellitus (T2DM) has shown a continuous increase in the number of patients in recent decades. Most anti-T2DM drugs tend to cause some side effects. Given the pathogenesis of T2DM, natural products have emerged as an important source of anti-T2DM drugs. This article reviews natural products with potential hypoglycemic activity from 2019 to 2023. A total of 200 previously natural products were discovered on SciFinder, PubMed and Web of Science. These products were categorized based on their structural frameworks and their biological activities were summarized. Although the mechanisms of action of most compounds are unclear, these compounds could still serve as candidates for the development of lead compounds. Therefore, further structure and activity research of natural products will significantly contribute to the development of potential anti-T2DM drugs.

Keywords: 2019-20231; Anti-T2DM candidate drugs; Anti-diabetic activity; Chemical structures; Contents; Natural products; Natural products with potential hypoglycemic activity in T2DM; T2DM.

Publication types

  • Review

MeSH terms

  • Biological Products* / chemistry
  • Biological Products* / pharmacology
  • Diabetes Mellitus, Type 2* / drug therapy
  • Humans
  • Hypoglycemic Agents* / chemistry
  • Hypoglycemic Agents* / pharmacology
  • Molecular Structure
  • Structure-Activity Relationship


  • Biological Products
  • Hypoglycemic Agents