The Impact of Infant Bacille Calmette-Guérin Vaccination on the Immunogenicity of Other Vaccines: A Randomized Exploratory Study

Pediatr Infect Dis J. 2024 Aug 1;43(8):809-812. doi: 10.1097/INF.0000000000004373. Epub 2024 May 8.

Abstract

The effect of the Bacille Calmette-Guérin (BCG) vaccine on the immunogenicity of separately administered serogroup C meningococcal vaccine and other vaccinations was examined in 28 infants randomized to receive BCG at age ≤7 days, at 3 months or after study completion. Immunogenicity of the serogroup C meningococcal vaccine and other routine vaccines might be improved when BCG is administered in early infancy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Antibodies, Bacterial / blood
  • BCG Vaccine* / administration & dosage
  • BCG Vaccine* / immunology
  • Female
  • Humans
  • Immunogenicity, Vaccine
  • Infant
  • Infant, Newborn
  • Male
  • Meningococcal Vaccines* / administration & dosage
  • Meningococcal Vaccines* / immunology
  • Vaccination

Substances

  • BCG Vaccine
  • Meningococcal Vaccines
  • Antibodies, Bacterial