RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-2-butanol, CAS Registry Number 103-05-9

A M Api; A Bartlett; D Belsito; D Botelho; M Bruze; A Bryant-Freidrich; G A Burton Jr; M A Cancellieri; H Chon; M L Dagli; W Dekant; C Deodhar; K Farrell; A D Fryer; L Jones; K Joshi; A Lapczynski; M Lavelle; I Lee; H Moustakas; J Muldoon; T M Penning; G Ritacco; N Sadekar; I Schember; T W Schultz; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar; Y Tokura

doi:10.1016/j.fct.2024.114712

RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-2-butanol, CAS Registry Number 103-05-9

Food Chem Toxicol. 2024 Jul:189 Suppl 1:114712. doi: 10.1016/j.fct.2024.114712. Epub 2024 May 6.

Authors

A M Api¹, A Bartlett¹, D Belsito², D Botelho¹, M Bruze³, A Bryant-Freidrich⁴, G A Burton Jr⁵, M A Cancellieri¹, H Chon¹, M L Dagli⁶, W Dekant⁷, C Deodhar¹, K Farrell¹, A D Fryer⁸, L Jones¹, K Joshi¹, A Lapczynski¹, M Lavelle¹, I Lee¹, H Moustakas¹, J Muldoon¹, T M Penning⁹, G Ritacco¹, N Sadekar¹, I Schember¹, T W Schultz¹⁰, F Siddiqi¹, I G Sipes¹¹, G Sullivan¹², Y Thakkar¹, Y Tokura¹³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
² Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.
⁴ Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI, 48202, USA.
⁵ Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁶ Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁷ Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
⁸ Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
⁹ Member of Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
¹⁰ Member Expert Panel for Fragrance Safety, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.
¹¹ Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹² Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: gsullivan@rifm.org.
¹³ Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

PMID: 38718914
DOI: 10.1016/j.fct.2024.114712

No abstract available

Publication types

Review

MeSH terms

Animals
Butanols / chemistry
Butanols / toxicity
Consumer Product Safety
Databases, Chemical
Endpoint Determination
Humans
No-Observed-Adverse-Effect Level
Odorants*
Perfume* / chemistry
Perfume* / toxicity
Risk Assessment
Toxicity Tests

Substances

Perfume
Butanols