Interactions between platelets and the cancer immune microenvironment

Crit Rev Oncol Hematol. 2024 Jul:199:104380. doi: 10.1016/j.critrevonc.2024.104380. Epub 2024 May 7.


Cancer is a leading cause of death in both China and developed countries due to its high incidence and low cure rate. Immune function is closely linked to the development and progression of tumors. Platelets, which are primarily known for their role in hemostasis, also play a crucial part in the spread and progression of tumors through their interaction with the immune microenvironment. The impact of platelets on tumor growth and metastasis depends on the type of cancer and treatment method used. This article provides an overview of the relationship between platelets and the immune microenvironment, highlighting how platelets can either protect or harm the immune response and cancer immune escape. We also explore the potential of available platelet-targeting strategies for tumor immunotherapy, as well as the promise of new platelet-targeted tumor therapy methods through further research.

Keywords: Adaptive immunity; Blood platelets; Immunomodulation; Immunotherapy; Innate immunity; Neoplasms; Platelet inhibition; Tumor escape.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Platelets* / immunology
  • Humans
  • Immunotherapy / methods
  • Neoplasms* / immunology
  • Neoplasms* / pathology
  • Neoplasms* / therapy
  • Tumor Escape
  • Tumor Microenvironment* / immunology