Intracranial hemorrhage in utero due to isoimmune neonatal thrombocytopenia

Obstet Gynecol. 1985 Mar;65(3 Suppl):20S-21S.

Abstract

A case is presented of isoimmune neonatal thrombocytopenia complicated by spontaneous intracranial hemorrhage in utero. Maternal platelets were found to be negative for the PLA1, Baka, and HLA-A2 antigens. The present case demonstrates that the classical conservative approach of elective cesarean section can not guarantee against this crippling event.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Human Platelet*
  • Blood Platelets / immunology*
  • Cerebral Hemorrhage / diagnosis
  • Cerebral Hemorrhage / etiology*
  • Cesarean Section
  • Echoencephalography
  • Female
  • Fetal Diseases / etiology*
  • HLA Antigens / analysis
  • HLA-A2 Antigen
  • Humans
  • Infant, Newborn
  • Integrin beta3
  • Isoantibodies / analysis
  • Isoantigens / analysis
  • Male
  • Pregnancy
  • Thrombocytopenia / complications
  • Thrombocytopenia / immunology*
  • Tomography, X-Ray Computed

Substances

  • 3a alloantigen, human
  • Antigens, Human Platelet
  • HLA Antigens
  • HLA-A2 Antigen
  • ITGB3 protein, human
  • Integrin beta3
  • Isoantibodies
  • Isoantigens