Potential therapeutic strategies to halt viral neuroinvasion

Rev Med Virol. 2024 May;34(3):e2539. doi: 10.1002/rmv.2539.


The viral infection of the central nervous system is a significant public health concern. So far, most clinical cases of viral neuroinvasion are dealt with supportive and/or symptomatic treatments due to the unavailability of specific treatments. Thus, developing specific therapies is required to alleviate neurological symptoms and disorders. In this review, we shed light on molecular aspects of viruses' entry into the brain which upon targeting with specific drugs have shown promising efficacy in vitro and in preclinical in vivo model systems. Further assessing the therapeutic potential of these drugs in clinical trials may offer opportunities to halt viral neuroinvasion in humans.

Keywords: central nervous system infections; drug therapy; inflammation; viruses.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents* / pharmacology
  • Antiviral Agents* / therapeutic use
  • Brain / drug effects
  • Brain / pathology
  • Brain / virology
  • Central Nervous System Viral Diseases / drug therapy
  • Central Nervous System Viral Diseases / virology
  • Humans
  • Virus Internalization / drug effects


  • Antiviral Agents