Ceruletide intravenous dose-response study by a simplified scintigraphic technique

AJR Am J Roentgenol. 1985 Apr;144(4):733-7. doi: 10.2214/ajr.144.4.733.


The intravenous dose response of a ceruletide diethylamine (ceruletide) was established by a simplified scintigraphic technique where multiple graded doses were given sequentially on a single occasion. The gallbladder volume was represented nongeometrically by 99mTc-IDA counts. The mean latent period, ejection period, and ejection rate were similar for all four groups of subjects given 1-20 ng/kg of ceruletide. The mean (+/- SD) ejection fractions after 1, 5, 10, and 15 ng/kg of ceruletide as the single dose were 19.4 +/- 11.9%, 59.6 +/- 26.0%, 55.2 +/- 23.3%, and 67.8 +/- 8.7%, respectively. These ejection fractions were similar to the values when the identical dose of ceruletide was administered sequentially either before or after another dose. A dose of 5 ng/kg produced the most physiologic type of emptying. Intravenous doses of 10 ng/kg and larger caused adverse reactions in 42% of the total doses in the form of abdominal pain, nausea, systolic and diastolic hypotension, or bradycardia. It is concluded that the dose response of a cholecystokininlike agent (ceruletide) can be established reliably by a scintigraphic technique where multiple graded doses are given on a single occasion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Ceruletide / administration & dosage
  • Ceruletide / physiology*
  • Cholecystokinin / physiology
  • Dose-Response Relationship, Drug
  • Female
  • Gallbladder / diagnostic imaging
  • Gallbladder / physiology*
  • Humans
  • Injections, Intravenous
  • Male
  • Radionuclide Imaging


  • Ceruletide
  • Cholecystokinin