Advances and challenges of the cell-based therapies among diabetic patients

Ramin Raoufinia; Hamid Reza Rahimi; Ehsan Saburi; Meysam Moghbeli

doi:10.1186/s12967-024-05226-3

Advances and challenges of the cell-based therapies among diabetic patients

J Transl Med. 2024 May 8;22(1):435. doi: 10.1186/s12967-024-05226-3.

Authors

Ramin Raoufinia^{1

2}, Hamid Reza Rahimi², Ehsan Saburi², Meysam Moghbeli³

Affiliations

¹ Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
² Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. moghbelim@mums.ac.ir.

Abstract

Diabetes mellitus is a significant global public health challenge, with a rising prevalence and associated morbidity and mortality. Cell therapy has evolved over time and holds great potential in diabetes treatment. In the present review, we discussed the recent progresses in cell-based therapies for diabetes that provides an overview of islet and stem cell transplantation technologies used in clinical settings, highlighting their strengths and limitations. We also discussed immunomodulatory strategies employed in cell therapies. Therefore, this review highlights key progresses that pave the way to design transformative treatments to improve the life quality among diabetic patients.

Keywords: Cell therapy; Diabetes; Immunosuppression; Islet; Translplantation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell- and Tissue-Based Therapy* / methods
Diabetes Mellitus* / therapy
Humans
Islets of Langerhans Transplantation
Stem Cell Transplantation*