[Acute coronary syndromes in diabetes mellitus : A comparative study between diabetics and non-diabetics patients in Senegalese urban environment]

Papa Momar Guissé; Sokhna Awa Balla Sall; Tacko Niang; Thierno Safaïou Doucouré; Mouhamed Cherif Mboup; Aliou Alassane Ngaïdé; Alassane Mbaye

doi:10.1016/j.ancard.2024.101767

[Acute coronary syndromes in diabetes mellitus : A comparative study between diabetics and non-diabetics patients in Senegalese urban environment]

Ann Cardiol Angeiol (Paris). 2024 May 8;73(3):101767. doi: 10.1016/j.ancard.2024.101767. Online ahead of print.

[Article in French]

Authors

Papa Momar Guissé¹, Sokhna Awa Balla Sall², Tacko Niang³, Thierno Safaïou Doucouré³, Mouhamed Cherif Mboup³, Aliou Alassane Ngaïdé⁴, Alassane Mbaye⁴

Affiliations

¹ Hôpital Principal de Dakar, Sénégal. Electronic address: papemomarguisse@yahoo.fr.
² Centre Hospitalier National de Pikine, Sénégal.
³ Hôpital Principal de Dakar, Sénégal.
⁴ Hôpital Général Idrissa Pouye, Sénégal.

PMID: 38723316
DOI: 10.1016/j.ancard.2024.101767

Abstract

Introduction: Diabetes Mellitus is a strong cardiovascular risk factor in which acute coronary syndromes (ACS) are thought to have a particular feature. We aimed to determine the characteristics of acute coronary syndromes in diabetics compared with non-diabetics patients.

Patients and methods: We carried out a prospective, descriptive and analytical study comparing diabetic and non-diabetic patients admitted for acute coronary syndrome to the cardiology department of Idrissa Pouye general hospital over a period of one year by studying socio-demographic, clinical, paraclinical, therapeutic and evolutionary parameters. We performed a multivariable logistic regression analysis to identify factors associated with chest pain and triple vessels disease.

Results: Our study included 139 patients, 61 with diabetes (44%) and 78 without diabetes (56%). Among diabetics, there was a predominance of women (p = 0.0001) in contrast to non-diabetics. The mean age was 62.7 ± 10.8 years in diabetics and 56.9 ± 13.5 years in non-diabetics (p = 0.006). Chest pain was found in 88.5% of diabetics and 97.4% of non-diabetics (p = 0.03). The mean HbA1c in diabetics was 9.4 ± 3.3%. ST elevation acute coronary syndrome was predominant in both groups. The mean GRACE score was 147 ± 29 in diabetics and 132 ± 28 in non-diabetics (p = 0.003). In multivariable analysis, only diabetes was associated with triple vessels disease (aOR (IC à 95%): 2,60 (1.29-6.83); p = 0.042). A total of 31% of diabetics and 43% of nondiabetics undergoes cardiac revascularization. There was no difference between the two groups in terms of complications. The mortality was 6.6% and 3.8% respectively among diabetics and non-diabetics (p = 0.49).

Conclusion: According to our study, diabetes is frequently encountered during acute coronary syndromes. It also shows that diabetics are more likely to be female and older, with more atypical symptoms and more severe coronary disease.

Keywords: Acute coronary syndrome; Diabetes mellitus; Diabète; Senegal; Syndromes coronaires aigus; Sénégal.

Publication types

English Abstract