The concept of Sfrp1+ transitional fibroblasts: the key to dissociating lineage heterogeneity and fate of invasive fibroblasts in pulmonary fibrosis?

Xue Liu; Xuexi Zhang; Jiurong Liang; Paul W Noble; Dianhua Jiang

doi:10.1183/13993003.00498-2024

The concept of Sfrp1⁺ transitional fibroblasts: the key to dissociating lineage heterogeneity and fate of invasive fibroblasts in pulmonary fibrosis?

Eur Respir J. 2024 May 9;63(5):2400498. doi: 10.1183/13993003.00498-2024. Print 2024 May.

Authors

Xue Liu¹, Xuexi Zhang¹, Jiurong Liang¹, Paul W Noble¹, Dianhua Jiang^{2

3}

Affiliations

¹ Department of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
² Department of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Dianhua.Jiang@CSHS.org.
³ Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Abstract

The novel concept of Sfrp1⁺ transitional fibroblasts has sparked novel points of interest: the mechanisms under which the Sfrp1⁺ transitional fibroblasts emerge and the in vivo functions of Sfrp1 and Sfrp1⁺ transitional fibroblasts in pulmonary fibrosis https://bit.ly/4aq6iAI

Publication types

Research Support, Non-U.S. Gov't
Letter
Editorial
Comment

MeSH terms

Animals
Cell Lineage
Fibroblasts* / metabolism
Humans
Intercellular Signaling Peptides and Proteins / metabolism
Membrane Proteins / genetics
Membrane Proteins / metabolism
Mice
Pulmonary Fibrosis* / metabolism
Pulmonary Fibrosis* / pathology

Substances

Membrane Proteins
Intercellular Signaling Peptides and Proteins