Cucurbit[8]uril-based supramolecular theranostics

J Nanobiotechnology. 2024 May 9;22(1):235. doi: 10.1186/s12951-024-02349-z.


Different from most of the conventional platforms with dissatisfactory theranostic capabilities, supramolecular nanotheranostic systems have unparalleled advantages via the artful combination of supramolecular chemistry and nanotechnology. Benefiting from the tunable stimuli-responsiveness and compatible hierarchical organization, host-guest interactions have developed into the most popular mainstay for constructing supramolecular nanoplatforms. Characterized by the strong and diverse complexation property, cucurbit[8]uril (CB[8]) shows great potential as important building blocks for supramolecular theranostic systems. In this review, we summarize the recent progress of CB[8]-based supramolecular theranostics regarding the design, manufacture and theranostic mechanism. Meanwhile, the current limitations and corresponding reasonable solutions as well as the potential future development are also discussed.

Keywords: Cucurbit[8]uril; Host–guest reactions; Self-assembly; Supramolecular nanomedicine; Supramolecular theranostics.

Publication types

  • Review

MeSH terms

  • Animals
  • Bridged-Ring Compounds* / chemistry
  • Heterocyclic Compounds, 2-Ring
  • Humans
  • Imidazoles* / chemistry
  • Imidazolidines
  • Macrocyclic Compounds
  • Nanoparticles / chemistry
  • Theranostic Nanomedicine* / methods


  • Bridged-Ring Compounds
  • Imidazoles
  • cucurbit(8)uril
  • Heterocyclic Compounds, 2-Ring
  • Macrocyclic Compounds
  • Imidazolidines