Paediatric Atopic Dermatitis: The Unexpected Impact on Life with a Specific Look at the Molecular Level

Int J Mol Sci. 2024 Apr 27;25(9):4778. doi: 10.3390/ijms25094778.


Atopic dermatitis (AD) is a condition with a multifactorial aetiology that affects the skin. It most often begins at preschool age and involves the skin. The disease's main symptom is intense itching, which occurs especially at night and affects the child's sleep, negatively impacting the quality of life of affected children and, consequently, their families. The difficulty in resting during the night leads to many problems during the day, particularly behavioural disorders and difficulties in paying attention at school, which results in learning impairment. The unexpected symptoms of AD are caused by pathophysiological processes that include many molecular pathways and inflammatory cytokines such as IL-31, IL-1, IL-2, TNF-a, and IL-6. Drawing on a comprehensive review of the literature in PubMed/MedLine, our review offers an in-depth exploration of both the psychosocial impacts of AD and the molecular processes that contribute to this disorder.

Keywords: anxiety; atopic dermatitis; cognitive dysfunction; quality of life; school performance.

Publication types

  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Cytokines / metabolism
  • Dermatitis, Atopic* / psychology
  • Humans
  • Quality of Life*


  • Cytokines

Grants and funding

This research received no external funding.