Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study

Int J Mol Sci. 2024 Apr 27;25(9):4799. doi: 10.3390/ijms25094799.


Hydroxytyrosol (HT) is a bioactive olive oil phenol with beneficial effects in a number of pathological situations. We have previously demonstrated that an HT-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic-stroke-associated damage in mice. Our exploratory pilot study examined this effect in humans. Particularly, a nutritional supplement containing 15 mg of HT/day was administered to patients 24 h after the onset of stroke, for 45 days. Biochemical and oxidative-stress-related parameters, blood pressure levels, serum proteome, and neurological and functional outcomes were evaluated at 45 and 90 days and compared to a control group. The main findings were that the daily administration of HT after stroke could: (i) favor the decrease in the percentage of glycated hemoglobin and diastolic blood pressure, (ii) control the increase in nitric oxide and exert a plausible protective effect in oxidative stress, (iii) modulate the evolution of the serum proteome and, particularly, the expression of apolipoproteins, and (iv) be beneficial for certain neurological and functional outcomes. Although a larger trial is necessary, this study suggests that HT could be a beneficial nutritional complement in the management of human stroke.

Keywords: HbA₁c; blood pressure; hydroxytyrosol; ischemic stroke; lipid profile; neurological and functional outcomes; oxidative-stress-related markers; proteomics.

MeSH terms

  • Aged
  • Blood Pressure / drug effects
  • Dietary Supplements*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide / metabolism
  • Oxidative Stress* / drug effects
  • Phenylethyl Alcohol* / analogs & derivatives
  • Phenylethyl Alcohol* / pharmacology
  • Phenylethyl Alcohol* / therapeutic use
  • Pilot Projects
  • Stroke* / drug therapy


  • 3,4-dihydroxyphenylethanol
  • Phenylethyl Alcohol
  • Nitric Oxide