Molecular probes for super-resolution imaging of drug dynamics

Hongbao Fang; Mengmeng Wang; Pengfan Wei; Qian Liu; Yan Su; Hongke Liu; Yuncong Chen; Zhi Su; Weijiang He

doi:10.1016/j.addr.2024.115330

Molecular probes for super-resolution imaging of drug dynamics

Adv Drug Deliv Rev. 2024 May 10:210:115330. doi: 10.1016/j.addr.2024.115330. Online ahead of print.

Authors

Hongbao Fang¹, Mengmeng Wang², Pengfan Wei³, Qian Liu³, Yan Su³, Hongke Liu³, Yuncong Chen⁴, Zhi Su⁵, Weijiang He⁶

Affiliations

¹ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China. Electronic address: fanghb@njnu.edu.cn.
² Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; College of Life Science and Chemistry, Jiangsu Key Laboratory of Biological Functional Molecules, Jiangsu Second Normal University, Nanjing, Jiangsu 210013, China.
³ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
⁴ State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China. Electronic address: chenyc@nju.edu.cn.
⁵ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address: zhisu@njnu.edu.cn.
⁶ State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

PMID: 38735627
DOI: 10.1016/j.addr.2024.115330

Abstract

Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.

Keywords: Diseases treatment; Drug dynamics; Molecular probes; Super-resolution imaging.

Publication types

Review