Molecular probes for super-resolution imaging of drug dynamics

Adv Drug Deliv Rev. 2024 Jul:210:115330. doi: 10.1016/j.addr.2024.115330. Epub 2024 May 10.

Abstract

Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.

Keywords: Diseases treatment; Drug dynamics; Molecular probes; Super-resolution imaging.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Molecular Imaging / methods
  • Molecular Probes* / chemistry
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / metabolism

Substances

  • Molecular Probes
  • Pharmaceutical Preparations