Disseminated cerebral cryptococcoma mimicking glioblastoma - A case report."

Akshata Uppar; Prabhuraj Andiperumal Raj; H B Veenakumari; Samaddar Arghadip; Rose Dawn Bharath; Nagarathna S

doi:10.1016/j.ijmmb.2024.100609

Disseminated cerebral cryptococcoma mimicking glioblastoma - A case report."

Indian J Med Microbiol. 2024 May 19:49:100609. doi: 10.1016/j.ijmmb.2024.100609. Online ahead of print.

Authors

Akshata Uppar¹, Prabhuraj Andiperumal Raj², H B Veenakumari¹, Samaddar Arghadip¹, Rose Dawn Bharath³, Nagarathna S⁴

Affiliations

¹ Department of Neuromicrobiology, NIMHANS, Bengaluru, 29, India.
² Department of Neurosurgery, NIMHANS, Bengaluru, 29, India.
³ Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, 29, India.
⁴ Department of Neuromicrobiology, NIMHANS, Bengaluru, 29, India. Electronic address: nagarathnachandrashekar@gmail.com.

PMID: 38735642
DOI: 10.1016/j.ijmmb.2024.100609

Abstract

We discuss a rare instance of cryptococcoma caused by Cryptococcus gattii in a 55-year-old woman initially treated for suspected COVID bronchopneumonia. The diagnosis posed a challenge due to vague symptoms and unclear imaging findings suggesting malignancy. Postoperative samples confirmed the presence of Cryptococcus gattii through culture of brain tissue and blood. Appropriate therapy was initiated, but despite treatment, it led to a fatal outcome. The case emphasizes the crucial role of microbiologist in early diagnosis of fungal infections of Central Nervous System. Additionally, the delayed diagnosis in immunocompetent individuals highlights the critical need for early recognition and intervention to mitigate potentially fatal outcomes.

Keywords: Brain neoplasms; Cryptococcoma; Glioma; Immunocompetence.

Publication types

Case Reports