Dual stimuli-responsive upconversion nanoparticle-poly- N-isopropylacrylamide/DNA core-shell microgels

Soft Matter. 2024 May 22;20(20):4052-4056. doi: 10.1039/d4sm00258j.


Stimuli-responsive upconversion nanoparticle (UCNP)-poly-N-isopropylacrylamide (pNIPAM)/DNA core-shell microgels with tunable sizes and programmable functions have been prepared. Thanks to the near-infrared (NIR)-responsive UCNP cores and thermosensitive polymeric shells, functional DNA-incorporated microgels with high DNA activity and loading efficiency are obtained, and the activity of the loaded DNA structures can be smartly regulated by NIR illumination and temperature simultaneously.