Photoredox/Bismuth Relay Catalysis Enabling Reductive Alkylation of Nitroarenes with Aldehydes

Jinlian Li; Xing Chen; Shenxia Xie; Huabing Wang; Jiayu Mo; Huawen Huang

doi:10.1002/chem.202401456

Photoredox/Bismuth Relay Catalysis Enabling Reductive Alkylation of Nitroarenes with Aldehydes

Chemistry. 2024 May 13:e202401456. doi: 10.1002/chem.202401456. Online ahead of print.

Authors

Jinlian Li¹, Xing Chen², Shenxia Xie¹, Huabing Wang³, Jiayu Mo¹, Huawen Huang⁴

Affiliations

¹ Guangxi Medical University, School of Pharmacy, CHINA.
² Xiangtan University, college of chemistry, CHINA.
³ The First Affiliated Hospital of Guangxi Medical University, Department of Clinical Laboratory, CHINA.
⁴ Xiangtan University, College of Chemistry, xiangtan, 411105, Xiangtan, CHINA.

PMID: 38738505
DOI: 10.1002/chem.202401456

Abstract

The effective transition metal-free photoredox/bismuth dual catalytic reductive dialkylation of nitroarenes with benzaldehydes has been reported. The nitroarene redution through visible light-driven photoredox catalysis was integrated with subsequent reductive dialkylation of anilines under bismuth catalysis to enable the cascade reductive alkylation of nitroarenes with carbonyls. Salient features of this relay catalysis system include mild reaction conditions, no requirement for transition metal catalysts, easy handling, step-economy, and high selectivity.

Keywords: Photoredox catalysis; aldehydes; bismuth; nitroarenes; reductive alkylation.