Ocular vestibular evoked myogenic potentials in different types of amblyopia

Mahdi Sharifi; Sadegh Jafarzadeh; Mohammad Yaser Kiarudi; Samira Hassanzadeh; Masoud Rostami

doi:10.1080/08164622.2024.2352503

Ocular vestibular evoked myogenic potentials in different types of amblyopia

Clin Exp Optom. 2024 May 15:1-5. doi: 10.1080/08164622.2024.2352503. Online ahead of print.

Authors

Mahdi Sharifi¹, Sadegh Jafarzadeh², Mohammad Yaser Kiarudi³, Samira Hassanzadeh¹, Masoud Rostami¹

Affiliations

¹ Refractive Error Research Center, Department of Optometry, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Audiology, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Eye Research Center, Department of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 38749671
DOI: 10.1080/08164622.2024.2352503

Abstract

Clinical relevance: The visual system plays an important role in the development of the vestibular-ocular reflex (VOR). In clinical practice, the ocular vestibular evoked myogenic potential (oVEMP) test is used to assess contralateral VOR.

Background: This study sought to compare the oVEMP in patients with anisometropic, strabismic, and mixed amblyopia using unilateral and bilateral (simultaneous binaural) stimulation.

Methods: Forty-two amblyopic patients (20 males and 22 females) with a mean age of 10.48 ± 4.00 years (range: 5 - 20 years) were examined. The Titmus stereopsis test, alternate cover test, and best-corrected visual acuity were evaluated. Patients were divided into three groups: anisometropic, strabismic, and mixed amblyopia. The oVEMP responses including the amplitude of electrical activity (n1-p1 complex) and the latencies (n1 and p1) of the VOR responses were recorded under unilateral and bilateral stimulations.

Results: In the anisometropic and strabismic group, n1 latency was significantly faster in the non-amblyopic eyes compared to amblyopic eyes (Z = -2.04, p = 0.042, andZ = -2.54, p = 0.024 respectively). Mean p1 latency was significantly faster in the non-amblyopic eyes compared to the amblyopic eyes of the strabismic group (Z = -2.31, p = 0.011)In all groups, the p1 latency was faster in the non-amblyopic eye compared to bilateral stimulation (all, p < 0.05). In all groups, the n1-p1 amplitude was not significantly different between the two eyes, and between each eye and bilateral stimulation (all, p > 0.05). No significant correlation was found between the depth of amblyopia and n1 and p1 responses (all, p > 0.05). In all groups there was no significant difference in the latency of n1 and p1 between the amblyopic eye and bilateral stimulation (all, p > 0.05).

Conclusion: Regardless of its type, amblyopia affects vestibular-ocular reflex responses. Further research is warranted to clarify the effect of the disease and its treatment on the ocular-vestibular system.

Keywords: Amblyopia; oVEMP; vestibular-ocular reflex.