The great escape: a Shigella effector unlocks the septin cage

Nat Commun. 2024 May 15;15(1):4104. doi: 10.1038/s41467-024-48208-1.


Shigella, an important human pathogen, can secrete effector proteins to invade host cells and evade mechanisms of cell-autonomous immunity. In a new manuscript published in Nature Communications, Xian et al. report that the Shigella kinase effector OspG promotes the ubiquitination of septin cytoskeletal proteins to evade cage entrapment.

Publication types

  • Comment

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Dysentery, Bacillary / microbiology
  • Humans
  • Septins* / genetics
  • Septins* / metabolism
  • Shigella / metabolism
  • Shigella / pathogenicity