The role of Interleukin-22 in severe acute pancreatitis

Mol Med. 2024 May 15;30(1):60. doi: 10.1186/s10020-024-00826-7.


Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP. IL-22, a member of the IL-10 cytokine family, has garnered growing interest owing to its potential tissue-protective properties. Recently, emerging research has revealed its specific effects on pancreatic diseases, particularly SAP. This paper provides a review of the latest knowledge on the role of IL-22 and its viability as a therapeutic target in SAP.

Keywords: Autophagy; IL -22; Inflammation; SAP-induced multiorgan injury; Sever acute pancreatitis.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Humans
  • Interleukin-22*
  • Interleukins* / metabolism
  • Pancreatitis* / immunology
  • Pancreatitis* / metabolism