Abstract
Eight previously undescribed cevanine-type steroidal alkaloids, cirrhosinones I-N and cirrhosinols A-B, along with five known analogs, were isolated from the bulbs of Fritillaria cirrhosa D. Don. Their structures were elucidated on the basis of comprehensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses. All compounds revealed weak NO inhibitory activities in the LPS-stimulated NR8383 cells at the concentration of 20 μM, with inhibition ratios ranging from 5.1% to 14.3%.
Keywords:
Cevanine-type steroidal alkaloids; Fritillaria cirrhosan D. Don; Liliaceae.
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MeSH terms
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Alkaloids* / chemistry
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Alkaloids* / isolation & purification
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Alkaloids* / pharmacology
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Animals
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Cell Line
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Cevanes / chemistry
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Cevanes / isolation & purification
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Cevanes / pharmacology
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Fritillaria* / chemistry
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Plant Roots* / chemistry
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Rats
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Steroids / chemistry
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Steroids / isolation & purification
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Steroids / pharmacology
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Structure-Activity Relationship
Substances
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Alkaloids
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Cevanes
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Nitric Oxide
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Lipopolysaccharides
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Steroids