The genetics of acute anterior uveitis

Trans Ophthalmol Soc U K. 1985;104 ( Pt 3):248-9.

Abstract

Acute anterior uveitis (AAU), and the many diseases with which it is associated, may be inherited. The antigen HLA-B27, on the 6th chromosome, increases the risk of AAU twenty-fold. AAU is also associated with an unusual phenotype, MZ, on the 14th chromosome--particularly when the AAU is related to ankylosing spondylitis.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 6-12 and X
  • HLA Antigens / analysis
  • HLA-B27 Antigen
  • Humans
  • Middle Aged
  • Phenotype
  • Spondylitis, Ankylosing / complications
  • Uveitis, Anterior / complications
  • Uveitis, Anterior / genetics*
  • Uveitis, Anterior / immunology
  • alpha 1-Antitrypsin / analysis

Substances

  • HLA Antigens
  • HLA-B27 Antigen
  • alpha 1-Antitrypsin