The role of YAP/TAZ on joint and arthritis

FASEB J. 2024 May 31;38(10):e23636. doi: 10.1096/fj.202302273RR.


Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common forms of arthritis with undefined etiology and pathogenesis. Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ), which act as sensors for cellular mechanical and inflammatory cues, have been identified as crucial players in the regulation of joint homeostasis. Current studies also reveal a significant association between YAP/TAZ and the pathogenesis of OA and RA. The objective of this review is to elucidate the impact of YAP/TAZ on different joint tissues and to provide inspiration for further studying the potential therapeutic implications of YAP/TAZ on arthritis. Databases, such as PubMed, Cochran Library, and Embase, were searched for all available studies during the past two decades, with keywords "YAP," "TAZ," "OA," and "RA."

Keywords: YAP/TAZ; bone; cartilage; osteoarthritis; rheumatoid arthritis; synovium.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing* / genetics
  • Adaptor Proteins, Signal Transducing* / metabolism
  • Animals
  • Arthritis, Rheumatoid* / metabolism
  • Humans
  • Joints / metabolism
  • Joints / pathology
  • Osteoarthritis* / etiology
  • Osteoarthritis* / metabolism
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription Factors* / metabolism
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins / metabolism
  • YAP-Signaling Proteins* / metabolism


  • YAP1 protein, human
  • WWTR1 protein, human