Transient neurologic disturbances induced by high-dose methotrexate treatment

Cancer. 1985 Sep 15;56(6):1356-60. doi: 10.1002/1097-0142(19850915)56:6<1356::aid-cncr2820560623>;2-h.


Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose and more frequent administration of MTX-CF. In view of the transient nature of the abnormalities, a biochemical cause is implicated, and the mechanisms by which it may occur are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Neoplasms / drug therapy*
  • Child
  • Female
  • Humans
  • Leucovorin / administration & dosage
  • Leucovorin / therapeutic use
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Nervous System Diseases / chemically induced*
  • Osteosarcoma / drug therapy*


  • Leucovorin
  • Methotrexate