Antimicrobial susceptibility of Pneumocystis carinii in culture

Diagn Microbiol Infect Dis. 1985 Sep;3(5):381-7. doi: 10.1016/0732-8893(85)90076-8.

Abstract

Pneumocystis carinii from infected rats were cultured on infected WI-38 human lung fibroblasts. After cultures were established, medium was replaced by medium containing antimicrobials and supernate organisms counted at specified times. Results show that metronidazole had no effect, amphotericin B suppressed organisms at 5 but not 0.5 microgram/ml, and miconazole, chloroquine, trimethoprim-sulfamethoxazole, and pentamidine isethionate suppressed organisms at the concentrations tested.

Publication types

  • Comparative Study

MeSH terms

  • Amphotericin B / pharmacology*
  • Animals
  • Anti-Infective Agents / pharmacology*
  • Cell Line
  • Chloroquine / pharmacology*
  • Culture Media
  • Drug Combinations / pharmacology
  • Humans
  • Metronidazole / pharmacology
  • Miconazole / pharmacology
  • Pentamidine / pharmacology
  • Pneumocystis / drug effects*
  • Pneumocystis / growth & development
  • Rats
  • Rats, Inbred Strains
  • Sulfamethoxazole / pharmacology
  • Time Factors
  • Trimethoprim / pharmacology
  • Trimethoprim, Sulfamethoxazole Drug Combination

Substances

  • Anti-Infective Agents
  • Culture Media
  • Drug Combinations
  • Metronidazole
  • Pentamidine
  • Miconazole
  • Amphotericin B
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Chloroquine
  • Trimethoprim
  • Sulfamethoxazole