The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia

EMBO J. 1985 Jun;4(6):1461-5. doi: 10.1002/j.1460-2075.1985.tb03803.x.


We have examined the chromosomal location of human T cell-specific genes which are involved in antigen recognition and of a gene which specifically rearranges in T cells. The genes encoding both the variable and constant region segments of the T cell receptor alpha chain are found on chromosome 14 while the delta chain gene of the T cell receptor-associated T3 complex is localised to chromosome 11. Further, the two tandemly arranged T cell-specific rearranging genes, designated gamma, were mapped to chromosome 7, but apparently not closely linked to the previously mapped T cell receptor beta-chain gene. The locations of the three different genes, which undergo rearrangement in T cells, may correlate with the chromosomal breakpoints known to be involved in translocations within abnormal human T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 6-12 and X
  • Humans
  • Leukemia / genetics*
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes / ultrastructure*
  • Translocation, Genetic*


  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/M12959