Diagnostic performance of regional systematic biopsy for prostate cancer stratified by PI-RADS and histologic zones

Zhoujie Sun; Yi Liu; Wei Yu; He Wang; Qi Shen; Cuijian Zhang

doi:10.1186/s13244-024-01680-1

Diagnostic performance of regional systematic biopsy for prostate cancer stratified by PI-RADS and histologic zones

Insights Imaging. 2024 May 16;15(1):118. doi: 10.1186/s13244-024-01680-1.

Authors

Zhoujie Sun^#^{1

2

3}, Yi Liu^#^{1

2

3}, Wei Yu^#^{1

2

3}, He Wang⁴, Qi Shen^{1

2

3}, Cuijian Zhang^{5

6

7}

Affiliations

¹ Department of Urology, Peking University First Hospital, No.8 Xishiku St. Xicheng District, Beijing, China.
² Institute of Urology, Peking University, No.8 Xishiku St. Xicheng District, Beijing, China.
³ The National Urological Cancer Center of China, No.8 Xishiku St. Xicheng District, Beijing, China.
⁴ Department of Radiology, Peking University First Hospital, Beijing, 100034, China.
⁵ Department of Urology, Peking University First Hospital, No.8 Xishiku St. Xicheng District, Beijing, China. surgeon_zhang@126.com.
⁶ Institute of Urology, Peking University, No.8 Xishiku St. Xicheng District, Beijing, China. surgeon_zhang@126.com.
⁷ The National Urological Cancer Center of China, No.8 Xishiku St. Xicheng District, Beijing, China. surgeon_zhang@126.com.

^# Contributed equally.

Abstract

Objectives: To explore the diagnostic performance of targeted biopsy (TB) combined with regional systematic biopsy (RSB) in patients with different Prostate Imaging Reporting and Data System (PI-RADS) and histologic zones for prostate lesions.

Methods: This retrospective study included 1301 patients who underwent multiparametric MRI followed by combined MRI/US fusion-guided TB+systematic biopsy (SB) between January 2019 and October 2022. RSB was defined as the four perilesional SB cores adjacent to an MRI-positive lesion. Cancer detection rates were calculated for TB + SB, TB, SB, and TB + RSB, while the McNemar test was utilized for multiple comparisons among them. Subgroup analyses were performed based on different Pl-RADS and histologic zones.

Results: Of 1301 included participants (median age, 68 years; interquartile range, 63-74 years), 16,104 total biopsy cores were performed. TB + RSB detected clinically significant prostate cancer in 70.9% (922/1301) of patients, which was significantly higher than TB (67.4%, p < 0.001) or SB (67.5%, p < 0.001) but similar to TB + SB (71.0%, p = 0.50). Compared with TB + SB, TB + RSB required fewer median biopsy cores (6.3 vs. 12.4, p < 0.001) and had a higher proportion of positive cores (56.3% vs. 39.0%, p < 0.001). Subgroup analysis showed that TB had outstanding sensitivity for detecting PI-RADS 5 lesions in the PZ.

Conclusions: Compared with TB + SB, TB + RSB achieved a similar clinically significant prostate cancer detection rate while requiring fewer biopsy cores and exhibiting higher diagnostic efficiency.

Critical relevance statement: For MRI-positive prostate lesions, targeted biopsy combined with regional systematic biopsy could serve as an alternative diagnostic approach to targeted biopsy combined with systematic biopsy.

Key points: The scheme of prostate biopsy needs to be optimized. Regional systematic biopsy decreases the total number of cores taken. Targeted biopsies combined with regional systematic biopsies improve prostate diagnostic efficiency.

Keywords: Image-guided biopsy; Magnetic resonance imaging; Prostatic neoplasms.

Grants and funding

No. 2020SF24/the Scientific Research Seed Fund of Peking University First Hospital