An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH

Yaxin Sun; Yanyun Mao; Tianwen Bai; Tianqing Ye; Yanfei Lin; Fang Wang; Lei Li; Longhua Guo; Haiying Liu; Jianbo Wang

doi:10.1039/d4cc01378f

An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH

Chem Commun (Camb). 2024 Jun 4;60(46):5932-5935. doi: 10.1039/d4cc01378f.

Authors

Yaxin Sun¹, Yanyun Mao², Tianwen Bai², Tianqing Ye², Yanfei Lin², Fang Wang¹, Lei Li², Longhua Guo², Haiying Liu³, Jianbo Wang²

Affiliations

¹ College of Pharmacy, Zhejiang University of Technology, Hangzhou, 310014, China.
² Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. guolh@zjxu.edu.cn.
³ Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. hyliu@mtu.edu.

PMID: 38757567
DOI: 10.1039/d4cc01378f

Abstract

A novel NIR fluorescent probe based on quinoline-conjugated benzo[cd]indol dual-salt for NADH was developed. This probe swiftly detects and responds sensitively to both endogenous and exogenous NADH alterations, enabling imaging of NADH fluctuations in type II diabetic and AD model cells.

MeSH terms

Animals
Diabetes Mellitus, Type 2
Fluorescent Dyes* / chemical synthesis
Fluorescent Dyes* / chemistry
Humans
Infrared Rays
Mitochondria* / chemistry
Mitochondria* / metabolism
NAD* / analysis
NAD* / chemistry
Optical Imaging
Quinolines / chemistry

Substances

Fluorescent Dyes
NAD
Quinolines