Artificial intelligence augmented home sleep apnea testing device study (AISAP study)

PLoS One. 2024 May 17;19(5):e0303076. doi: 10.1371/journal.pone.0303076. eCollection 2024.


Study objective: This study aimed to prospectively validate the performance of an artificially augmented home sleep apnea testing device (WVU-device) and its patented technology.

Methodology: The WVU-device, utilizing patent pending (US 20210001122A) technology and an algorithm derived from cardio-pulmonary physiological parameters, comorbidities, and anthropological information was prospectively compared with a commercially available and Center for Medicare and Medicaid Services (CMS) approved home sleep apnea testing (HSAT) device. The WVU-device and the HSAT device were applied on separate hands of the patient during a single night study. The oxygen desaturation index (ODI) obtained from the WVU-device was compared to the respiratory event index (REI) derived from the HSAT device.

Results: A total of 78 consecutive patients were included in the prospective study. Of the 78 patients, 38 (48%) were women and 9 (12%) had a Fitzpatrick score of 3 or higher. The ODI obtained from the WVU-device corelated well with the HSAT device, and no significant bias was observed in the Bland-Altman curve. The accuracy for ODI > = 5 and REI > = 5 was 87%, for ODI> = 15 and REI > = 15 was 89% and for ODI> = 30 and REI of > = 30 was 95%. The sensitivity and specificity for these ODI /REI cut-offs were 0.92 and 0.78, 0.91 and 0.86, and 0.94 and 0.95, respectively.

Conclusion: The WVU-device demonstrated good accuracy in predicting REI when compared to an approved HSAT device, even in patients with darker skin tones.

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Artificial Intelligence*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polysomnography / instrumentation
  • Polysomnography / methods
  • Prospective Studies
  • Sleep Apnea Syndromes* / diagnosis
  • Sleep Apnea Syndromes* / physiopathology

Grants and funding

This work is supported in part by funds from the National Science Foundation (NSF: Award # 2125872) and the Department of Medicine, West Virginia University, Morgantown, WV The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.