S100A4 makes two appearances in mechanisms leading to fibrosis

J Biol Chem. 2024 May 15;300(6):107385. doi: 10.1016/j.jbc.2024.107385. Online ahead of print.

Abstract

Non-muscle myosin 2 (NM2) is known to play an important role in myofibroblast transdifferentiation, a hallmark of fibrotic disorders. In a recent JBC article, Southern et al. demonstrate that endogenous S100A4, a calcium- and NM2-binding protein acts as a mechanoeffector in this process. Since extracellular S100A4 is also involved in fibrogenesis by triggering the inflammatory response, this small protein appears to contribute to fibrosis via at least two distinct mechanisms.