Research progress in Alzheimer's disease and bone-brain axis

Fan Zhang; Wei Zhang

doi:10.1016/j.arr.2024.102341

Research progress in Alzheimer's disease and bone-brain axis

Ageing Res Rev. 2024 May 15:98:102341. doi: 10.1016/j.arr.2024.102341. Online ahead of print.

Authors

Fan Zhang¹, Wei Zhang²

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Electronic address: ttyyzw@163.com.

PMID: 38759893
DOI: 10.1016/j.arr.2024.102341

Abstract

Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.

Keywords: Alzheimer's disease; Bone-brain axis; Orthopedic diseases; Research progress.

Publication types

Review