Current updates in precision and personalized medicine in sepsis and trauma

Surgery. 2024 Aug;176(2):541-543. doi: 10.1016/j.surg.2024.03.048. Epub 2024 May 17.


Precision and personalized medicine remain an elusive but illustrious goal in the realm of critical care, particularly in the areas of trauma and sepsis. These aims specifically refer to data gathering, interpretation, and treatment application on an individualized basis in the clinical care of patients. Until now, personalized medicine has mainly remained focused on genetics and epigenetic phenomena and has propelled clinical care forward, especially in the field of oncology. Advances in technology and methodology continue to proliferate in early-phase research, and some of these advancements are well poised to break into the clinical sphere of critical care. Here, we describe 2 topics at the forefront of investigation with potent and imminent potential for clinical application.

Publication types

  • Review

MeSH terms

  • Critical Care / methods
  • Humans
  • Precision Medicine* / methods
  • Sepsis* / diagnosis
  • Sepsis* / therapy
  • Wounds and Injuries* / complications
  • Wounds and Injuries* / diagnosis
  • Wounds and Injuries* / therapy