Objective: To observe the clinical efficacy and safety of fire dragon cupping in prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in breast cancer.
Methods: Sixty breast cancer patients receiving medium-high emetogenic chemotherapy regimen were randomly divided into an observation group (30 cases, 3 cases dropped out) and a control group (30 cases, 3 cases dropped out). In both groups, 5 mg tropisetron hydrochloride was given intravenously on the day of chemotherapy and 1st to 3rd days after chemotherapy. In the observation group, fire dragon cupping on the abdomen was applied on 1st, 3rd and 5th days after chemotherapy. The incidence of nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, the severity of nausea, vomiting on 1st to 6th days after chemotherapy, and the duration of nausea, vomiting, loss of appetite were observed in the two groups. The self-rating anxiety scale (SAS) score, general comfort questionnaire scale (GCQ) score before and after treatment and remedy antiemetic medication were observed in the two groups, and the safety was evaluated.
Results: On 2nd to 6th days after chemotherapy, the number of patients with nausea, loss of appetite and abdominal distension and nausea scores in the observation group were lower than those in the control group (P<0.05). On 1st to 3rd days after chemotherapy, the number of patients with vomiting and vomiting scores in the observation group were lower than those in the control group (P<0.05). The duration of nausea, vomiting and loss of appetite in the observation group were shorter than those in the control group (P<0.05). In the observation group, there was no significant difference in SAS and GCQ scores before and after treatment (P>0.05). After treatment, the GCQ score in the control group was decreased compared with that before treatment (P<0.05). After treatment, there was no significant difference in SAS and GCQ scores between the two groups (P>0.05). There was no significant difference in the number of patients using remedy medication between the two groups (P>0.05). No adverse reaction occurred during treatment in both groups.
Conclusion: Fire dragon cupping can effectively reduce the incidence of nausea, vomiting, loss of appetite and the severity of nausea, vomiting related to chemotherapy in breast cancer, and improve patient comfort, and have good safety.
目的：观察火龙罐防治乳腺癌化疗相关性恶心呕吐（CINV）的疗效及安全性。方法：将60例接受中高度致呕化疗方案的乳腺癌患者随机分为观察组（30例，脱落3例）和对照组（30例，脱落3例）。两组患者均在化疗当天及化疗后第1~3天给予盐酸托烷司琼5 mg静脉滴注，观察组在化疗后第1、3、5天行腹部火龙罐治疗。记录两组患者化疗后第1~6天恶心、呕吐、纳差、腹痛、腹胀发生情况，恶心、呕吐严重程度，恶心、呕吐、纳差持续天数，观察两组患者治疗前后焦虑自评量表（SAS）评分、舒适状况量表（GCQ）评分及补救止呕用药情况，并评估治疗安全性。结果：观察组患者化疗后第2~6天恶心、纳差、腹胀发生例数及恶心评分低于对照组（P<0.05），化疗后第1~3天呕吐发生例数及呕吐评分低于对照组（P<0.05），观察组患者恶心、呕吐、纳差持续天数短于对照组（P<0.05）。观察组治疗后SAS评分、GCQ评分与治疗前比较差异无统计学意义（P>0.05），对照组GCQ评分较治疗前降低（P<0.05）；治疗后两组间SAS评分、GCQ评分比较差异无统计学意义（P>0.05）。两组患者补救用药例数比较差异无统计学意义（P>0.05）。两组患者治疗过程中均无不良反应发生。结论：火龙罐治疗能有效降低乳腺癌化疗相关恶心、呕吐、纳差的发生率及恶心、呕吐程度，提高患者舒适度，且安全性较好。.
Keywords: breast cancer; chemotherapy; fire dragon cupping; nausea and vomiting; tropisetron hydrochloride.