MRI detection of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) on T1WI-CHESS

Elly Arizono; Zen-Ichi Tanei; Keiya Iijima; Yukio Kimura; Yoko Shigemoto; Hiroyuki Maki; Midori Kusama; Kumiko Murayama; Masaki Iwasaki; Takashi Saito; Yuko Saito; Kazuhiro Saito; Noriko Sato

doi:10.1016/j.ebr.2024.100674

MRI detection of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) on T1WI-CHESS

Epilepsy Behav Rep. 2024 May 8:26:100674. doi: 10.1016/j.ebr.2024.100674. eCollection 2024.

Authors

Elly Arizono^{1

2}, Zen-Ichi Tanei³, Keiya Iijima⁴, Yukio Kimura¹, Yoko Shigemoto¹, Hiroyuki Maki¹, Midori Kusama¹, Kumiko Murayama⁵, Masaki Iwasaki⁴, Takashi Saito⁶, Yuko Saito⁷, Kazuhiro Saito², Noriko Sato¹

Affiliations

¹ Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
² Department of Radiology, Tokyo Medical University, School of Medicine, Tokyo, Japan.
³ Department of Cancer Pathology, Hokkaido University, Faculty of Medicine, Hokkaido, Japan.
⁴ Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
⁵ Department of Genome Medicine Development, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
⁶ Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
⁷ Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Abstract

Mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) is a recently proposed epileptogenic entity that is difficult to detect on MRI. We present a case of MOGHE that was successfully detected on T1WI-chemical shift-selective saturation (CHESS) MRI. The clinical presentation, MRI including T1WI-CHESS, functional images, and pathology findings of a 14-year-old Japanese girl diagnosed with MOGHE are described. T1WI-CHESS revealed an abnormal high signal along the affected lesion, whereas the findings shown by the other MR sequences were less obvious; interictal fluorodeoxyglucose-positron emission tomography indicated slightly decreased accumulation in the lesion, and subtraction ictal single photon emission computed tomography co-registered to MRI showed an increased blood flow. Together these observations suggest that T1WI-CHESS may be a useful MR sequence for detecting the lesions in patients with MOGHE.

Keywords: CHESS; MOGHE; MRI; epilepsy.

Publication types

Case Reports