A systematic review: Sinomenine

Heliyon. 2024 May 4;10(9):e29976. doi: 10.1016/j.heliyon.2024.e29976. eCollection 2024 May 15.


Sinomenine (SIN), an alkaloid derived from the traditional Chinese medicine, Caulis Sinomenii, has been used as an anti-inflammatory drug in China for over 30 years. With the continuous increase in research on the pharmacological mechanism of SIN, it has been found that, in addition to the typical rheumatoid arthritis (RA) treatment, SIN can be used as a potentially effective therapeutic drug for anti-tumour, anti-renal, and anti-nervous system diseases. By reviewing a large amount of literature and conducting a summary analysis of the literature pertaining to the pharmacological mechanism of SIN, we completed a review that focused on SIN, found that the current research is insufficient, and offered an outlook for future SIN development. We hope that this review will increase the public understanding of the pharmacological mechanisms of SIN, discover SIN research trial shortcomings, and promote the effective treatment of immune diseases, inflammation, and other related diseases.

Keywords: Chronic inflammatory diseases; Natural compound; Pharmacological mechanism; Rheumatoid arthritis; Sinomenine; Therapeutic drugs.

Publication types

  • Review