The role of pre-onset hair hormone in predicting the prognosis of patients with severe pneumonia and acute COVID-19 outbreak

Yuanyuan Jia; Deyi Qi; Tiantian Wang; Yuyao Zhang; Xufeng Chen; Huihua Deng; Dianhuai Meng

doi:10.1016/j.heliyon.2024.e30636

The role of pre-onset hair hormone in predicting the prognosis of patients with severe pneumonia and acute COVID-19 outbreak

Heliyon. 2024 May 3;10(9):e30636. doi: 10.1016/j.heliyon.2024.e30636. eCollection 2024 May 15.

Authors

Yuanyuan Jia¹, Deyi Qi², Tiantian Wang¹, Yuyao Zhang¹, Xufeng Chen³, Huihua Deng², Dianhuai Meng¹

Affiliations

¹ Rehabilitation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
² School of Biological Science & Medical Engineering, Southeast University, Nanjing, 211189, Jiangsu, China.
³ Department of Emergency and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.

Abstract

Numerous research works have investigated the potential impact of endocrine hormones on the severity of COVID-19-related pneumonia in individuals. However, there are few studies on the effect of pre-onset neuroendocrine hormones on the prognosis of COVID-19 patients. This study looked into the prognostic value of pre-onset hair hormone levels in COVID-19 infected individuals. This study included 27 patients with COVID-19 and collected patient information and laboratory indicators. The hormone levels in hair were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Within 28 days, 63 % of the patients in this study passed away. With 28-day mortality as the outcome index, urea nitrogen, CURB-65 score and pneumonia severity score (PSI) of 2 groups were statistically significant (P < 0.05). Among all hormone levels detected in hair, only progesterone level was substantially correlated negatively with COVID-19 patients' 28-day mortality(P < 0.05). The level of progesterone in hair was substantially adversely connected with the death rate at 28 days of COVID-19 patients, according to correlation and logistic regression analysis(P < 0.05). Among patients with COVID-19 pneumonia, hair progesterone levels were strongly associated with 28-day mortality, which emphasizes hair progesterone's importance as a prognostic factor.

Keywords: COVID 19; Hair hormone; Mortality; Progesterone; Prognosis; Severe pneumonia.