Disseminated herpes simplex virus type 1 infection manifested as extensive oral ulcers, pneumonitis, and ileo-colitis in a neutropenic patient post-chemotherapy for osteosarcoma

Samadhi Patamatamkul; Narittee Sukswai; Onjira Mangkalamanee; Rongpong Plongla

doi:10.1016/j.idcr.2024.e01978

Disseminated herpes simplex virus type 1 infection manifested as extensive oral ulcers, pneumonitis, and ileo-colitis in a neutropenic patient post-chemotherapy for osteosarcoma

IDCases. 2024 May 3:36:e01978. doi: 10.1016/j.idcr.2024.e01978. eCollection 2024.

Authors

Samadhi Patamatamkul^{1

2}, Narittee Sukswai³, Onjira Mangkalamanee², Rongpong Plongla^{2

4}

Affiliations

¹ Department of Medicine, Faculty of Medicine, Suddhavej Hospital, Mahasarakham University, Maha Sarakham, Thailand.
² Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial, Thai Red Cross Society, Bangkok, Thailand.
³ Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
⁴ Center of Excellence in Antimicrobial Resistance and Stewardship, Chulalongkorn University, Bangkok, Thailand.

Abstract

Herpes simplex virus (HSV) is a common cause of recurrent oropharyngeal ulcers or stomatitis resulting from the reactivation of latent infection since childhood. Extensive ulceration and dissemination to vital organs such as pneumonitis or colitis is mostly encountered among hematologic malignancy or hematologic stem cell transplants. We hereby reported a case with osteosarcoma who developed disseminated HSV infection during neutropenia after chemotherapy.

Keywords: Chemotherapy; Herpes simplex virus; Lymphopenia; Sarcoma.

Publication types

Case Reports