Using Omics to Identify Novel Therapeutic Targets in Heart Failure

Circ Genom Precis Med. 2024 Jun;17(3):e004398. doi: 10.1161/CIRCGEN.123.004398. Epub 2024 May 20.


Omics refers to the measurement and analysis of the totality of molecules or biological processes involved within an organism. Examples of omics data include genomics, transcriptomics, epigenomics, proteomics, metabolomics, and more. In this review, we present the available literature reporting omics data on heart failure that can inform the development of novel treatments or innovative treatment strategies for this disease. This includes polygenic risk scores to improve prediction of genomic data and the potential of multiomics to more efficiently identify potential treatment targets for further study. We also discuss the limitations of omic analyses and the barriers that must be overcome to maximize the utility of these types of studies. Finally, we address the current state of the field and future opportunities for using multiomics to better personalize heart failure treatment strategies.

Keywords: drug discovery; genomics; heart failure; multiomics; polygenic risk score; therapeutics; transcriptomics.

Publication types

  • Review

MeSH terms

  • Epigenomics* / methods
  • Genomics*
  • Heart Failure* / drug therapy
  • Heart Failure* / genetics
  • Heart Failure* / metabolism
  • Humans
  • Metabolomics*
  • Precision Medicine
  • Proteomics*