Impact of Prevalent Dietary Pattern on Serum Vitamin B12 Status and Its Association With Inflammation Among Reproductive Age Women

Mohammad Ashraf Ganie; Rohina Bashir; Tajali Sehar; Mir Asrar; Shahid Khan; Saleem Baba; Nikhil Tandon; Vatsla Dhadwal; Vivekap Jyotsna; Sada Nand Dwivedi

doi:10.1002/mnfr.202300315

Impact of Prevalent Dietary Pattern on Serum Vitamin B12 Status and Its Association With Inflammation Among Reproductive Age Women

Mol Nutr Food Res. 2024 May 20:e2300315. doi: 10.1002/mnfr.202300315. Online ahead of print.

Authors

Mohammad Ashraf Ganie¹, Rohina Bashir^{1

2}, Tajali Sehar^{1

2}, Mir Asrar², Shahid Khan³, Saleem Baba¹, Nikhil Tandon³, Vatsla Dhadwal⁴, Vivekap Jyotsna³, Sada Nand Dwivedi⁵

Affiliations

¹ Departments of Endocrinology, Srinagar, India.
² Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.
³ Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
⁴ Department of Obstetricians and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
⁵ Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

PMID: 38766917
DOI: 10.1002/mnfr.202300315

Abstract

Scope: Association between vitamin B12 deficiency (VB12D) and dietary patterns being well documented has bearing on obstetrics and neonatal outcomes. However, relationship between VB12D and serum inflammatory markers (IMs), particularly in vegetarian diet and Polycystic ovary syndrome (PCOS), remains elusive. This cross-sectional study assesses VB12D and IMs among reproductive age women consuming different diets.

Methods and results: Nonvegetarian (PCOS, n = 104; healthy, n = 148) and vegetarian women (PCOS n = 112; healthy, n = 186) are for evaluated clinical, biochemical, hormonal assessment, inflammatory, and four vitamin B 12 (VB12) markers. VB12D is defined by Fedosov's wellness quotient (4cB12). Using 4cB12, prevalence of VB12D is discerned in 54.4% (PCOS: 72.1%; healthy 36.5%) and 93.4% (PCOS: 95.9%; healthy: 91.9%) among nonvegetarians and vegetarians, respectively. Vegetarian PCOS women depict lowest median (interquartile range [IQR]) of serum B12 76.2(72.6) pg mL^-1, holotranscobalamine (HTC) 37.9(11.3) and highest homocysteine (HCY) 40.32(6.0) µmol L^-1, methylmalonic acid (MMA) 352.26(156.7) nmol L^-1 with highest Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and IMs (Monocyte chemoattractant protein 1 (MCP-1), High sensitivity C-reactive protein (hs-CRP), Tumour Necrosis Factor alpha (TNF-α) and Interleukin 6 (IL-6)). Significant correlation of serum hs-CRP, TNF-α, and IL-6 with VB12 markers is observed.

Conclusion: The VB12D is rampant among reproductive age women that gets exacerbated by PCOS or vegetarian diet. It is directly correlated with magnitude of proinflammatory markers. The results carry substantial implications for public health policies aimed at improving preconception maternal VB12 status for better future pregnancy and offspring outcomes.

Keywords: inflammation; obstetric and neonatal outcomes; polycystic ovary syndrome; reproductive age women; vitamin B12 deficiency.

Abstract

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