Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Lin Kong; Rongyuan Zhang; Junyi Gong; Huan Wang; Lingyu Zhai; Dongfeng Dang; Qian Liu; Zheng Zhao; Ben Zhong Tang

doi:10.1039/d4cc01022a

Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Chem Commun (Camb). 2024 Jun 4;60(46):5960-5963. doi: 10.1039/d4cc01022a.

Authors

Lin Kong^{1

2}, Rongyuan Zhang², Junyi Gong², Huan Wang¹, Lingyu Zhai¹, Dongfeng Dang³, Qian Liu⁴, Zheng Zhao², Ben Zhong Tang^{2

5}

Affiliations

¹ College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China.
² School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China. zhaozheng@cuhk.edu.cn.
³ School of Science, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
⁴ Department of Urology, Tianjin First Central Hospital, Tianjin 300192, China.
⁵ Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

PMID: 38767007
DOI: 10.1039/d4cc01022a

Abstract

A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

MeSH terms

Animals
Anti-Bacterial Agents* / chemical synthesis
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Boron Compounds / chemistry
Boron Compounds / pharmacology
Methicillin-Resistant Staphylococcus aureus* / drug effects
Mice
Microbial Sensitivity Tests*
Photosensitizing Agents* / chemistry
Photosensitizing Agents* / pharmacology
Staphylococcal Infections / drug therapy

Substances

Photosensitizing Agents
Anti-Bacterial Agents
Boron Compounds