68Ga-DOTATATE PET/CT Detected Bone Metastasis Earlier Than 68Ga-FAPI PET/CT and 99mTc-MDP Bone Scintigraphy in a Patient With Nasopharyngeal Carcinoma

Jieling Zheng; Hongxu Zhu; Zezhong Shao; Weibing Miao

doi:10.1097/RLU.0000000000005289

68Ga-DOTATATE PET/CT Detected Bone Metastasis Earlier Than 68Ga-FAPI PET/CT and 99mTc-MDP Bone Scintigraphy in a Patient With Nasopharyngeal Carcinoma

Clin Nucl Med. 2024 May 15. doi: 10.1097/RLU.0000000000005289. Online ahead of print.

Authors

Jieling Zheng, Hongxu Zhu¹, Zezhong Shao, Weibing Miao

Affiliation

¹ Department of Nuclear Medicine, the Ningde Municipal Hospital of Ningde Normal University, Ningde.

PMID: 38768089
DOI: 10.1097/RLU.0000000000005289

Abstract

A 53-year-old man with newly diagnosed nasopharyngeal carcinoma (NPC) underwent 99mTc-MDP bone scintigraphy for the potential bone metastases, and paired 68Ga-DOTATATE and 68Ga-FAPI PET/CT for initial staging. 68Ga-DOTATATE PET/CT identified 2 abnormal foci with increased tracer uptake in the cervical vertebra and the ilium, whereas 68Ga-FAPI PET/CT and bone scan detected only the ilium lesion. A subsequent biopsy confirmed NPC metastasis in the ilium. Furthermore, baseline and follow-up bone scintigraphy revealed that the positive lesion in the cervical vertebra, as indicated in 68Ga-DOTATATE PET/CT, was also a bone metastasis. This case highlighted the potential superiority of 68Ga-DOTATATE in NPC.