Thoracic SMARCA4-Deficient Undifferentiated Tumor Mimicking a Pleural Mesothelioma on 18F-FDG PET/CT

Xueqi Chen; Guoqian Chen; Qian Li; Zhanli Fu

doi:10.1097/RLU.0000000000005285

Thoracic SMARCA4-Deficient Undifferentiated Tumor Mimicking a Pleural Mesothelioma on 18F-FDG PET/CT

Clin Nucl Med. 2024 May 15. doi: 10.1097/RLU.0000000000005285. Online ahead of print.

Authors

Xueqi Chen¹, Guoqian Chen², Qian Li³, Zhanli Fu¹

Affiliations

¹ From the Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
² Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
³ Department of Ultrasound, Shenzhen University General Hospital, Shenzhen, China.

PMID: 38768095
DOI: 10.1097/RLU.0000000000005285

Abstract

A 72-year-old woman, who was a nonsmoker, presented with chest distress persisting for over 10 days. Plain chest CT revealed thickening of the left pleura accompanied by hydrothorax. Subsequent 18F-FDG PET/CT showed irregular thickening involving the visceral, parietal, and interlobular pleura on the left side, with diffuse high avidity of 18F-FDG. The left pleural mesothelioma was suspected initially, but pathological examination from biopsied specimen later confirmed a thoracic SMARCA4-deficient undifferentiated tumor.