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Comparative Study
, 191 (1), 39-44

Sequence of the OXA2 Beta-Lactamase: Comparison With Other Penicillin-Reactive Enzymes

Comparative Study

Sequence of the OXA2 Beta-Lactamase: Comparison With Other Penicillin-Reactive Enzymes

J W Dale et al. FEBS Lett.

Abstract

The nucleotide sequence of the unusual plasmid-mediated OXA2 beta-lactamase is presented, and compared with other beta-lactamases. The OXA2 enzyme has similar features at the presumed active site, but no other significant regions of homology with other penicillin-reactive enzymes. The active site homology may therefore represent convergent evolution of otherwise dissimilar genes.

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