Sequence of the OXA2 beta-lactamase: comparison with other penicillin-reactive enzymes

FEBS Lett. 1985 Oct 21;191(1):39-44. doi: 10.1016/0014-5793(85)80989-3.


The nucleotide sequence of the unusual plasmid-mediated OXA2 beta-lactamase is presented, and compared with other beta-lactamases. The OXA2 enzyme has similar features at the presumed active site, but no other significant regions of homology with other penicillin-reactive enzymes. The active site homology may therefore represent convergent evolution of otherwise dissimilar genes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / analysis
  • Base Sequence
  • Penicillins / metabolism*
  • beta-Lactamases / analysis
  • beta-Lactamases / genetics*


  • Amino Acids
  • Penicillins
  • beta-Lactamases

Associated data

  • GENBANK/X03037