Cerebral blood flow with the continuous infusion of oxygen-15-labeled water

J Cereb Blood Flow Metab. 1985 Dec;5(4):566-75. doi: 10.1038/jcbfm.1985.85.


This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O. A whole-brain CBF model is described that permits the comparison of the CBF values determined using PET with those obtained using other methods. This model includes a correction for whole-brain recovery coefficient, a correction for the underestimation of flow due to the nonlinearity of the CBF model when considering tissue that includes both gray and white matter, the use of in vitro-determined brain-blood partition coefficients for gray and white matter, and a variation of the equilibrium model that permits the arterial concentration to vary. CBF values using this method compare well with values determined previously. Regional determinations using a brain overlay atlas are presented. Radiation dosimetry for the continuous infusion of H2(15)O is also included.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / metabolism
  • Cerebrovascular Circulation*
  • Humans
  • Infusions, Parenteral
  • Oxygen Radioisotopes*
  • Tomography, Emission-Computed
  • Water*


  • Oxygen Radioisotopes
  • Water