Rare Variant of Leprosy Reaction (Lucio Phenomenon): A Case Series

Int J Mycobacteriol. 2024 Jan 1;13(1):105-111. doi: 10.4103/ijmy.ijmy_184_23. Epub 2024 Mar 15.

Abstract

Lucio phenomenon (LP) is a variant of type two leprosy, characterized by necrotizing erythema, frequently found in neglected leprosy patient who experience delayed diagnosis or inappropriate treatment. Indonesia is in the third place for highest leprosy cases worldwide. Nonetheless, LP is less common, regardless being an endemic country. In this serial case, we describe the three cases of LP in lepromatous leprosy patients in Denpasar, Bali. All three cases came to our hospital with chronic wounds complained up to a year, accompanied by swollen leg, blisters, tingling sensation, and other symptoms. They had received no suitable treatment, proving LP as a neglected case in primary health care. After a period of treatment, however, patient lesions improved clinically with no physical disability. With this case series, a better understanding toward LP initial complains together with its natural history and further examination could be achieved; thus, improving the early diagnosis and management of LP.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Erythema / etiology
  • Erythema / pathology
  • Female
  • Humans
  • Indonesia
  • Leprostatic Agents* / therapeutic use
  • Leprosy / complications
  • Leprosy / diagnosis
  • Leprosy / drug therapy
  • Leprosy, Lepromatous / diagnosis
  • Leprosy, Lepromatous / drug therapy
  • Leprosy, Lepromatous / microbiology
  • Leprosy, Lepromatous / pathology
  • Male
  • Skin / microbiology
  • Skin / pathology

Substances

  • Leprostatic Agents