Sunscreen compound benzophenone-3 and its relationship with white blood cell counts

Abstract

Background: Evidence from animal models suggests a role for the organic ultraviolet filter benzophenone-3's (BP-3) on white blood cells (WBCs). However, BP-3's effect on WBCs in humans is unknown.

Materials and methods: We used National Health and Nutrition Examination Survey data from 2003 to 2016. We included participants >6 years with data on urinary BP-3, urinary creatinine, and WBC count. Quintiles of urinary creatinine-normalized BP-3 (CnBP-3) levels were used in linear regression models adjusting for age, gender, race, body mass index (BMI), smoking status, education level, family income to poverty threshold ratio, survey cycle, and season.

Results: Of the 16 959 participants, 8564 (50.5%) were females, 6602 (38.9%) were White, and 3870 (22.8%) were Black. The mean (standard deviation) age was 37.6 (22.7) years, BMI was 26.8 (7.40) kg/m², WBC count was 7.22 (2.53) × 10⁹/L, neutrophil count was 4.15 (1.86) × 10⁹/L, and lymphocyte count was 2.25 (1.33) × 10⁹/L and median (interquartile range) of CnBP-3 was 12.1 (44.9) µg/gm. The highest quintile of CnBP-3 was associated with significantly lower WBC and neutrophil counts compared to the lowest quintile of CnBP-3 (Δ quintiles = -137 × 10⁶/L, 95% CI: -249 to -24, p = 0.02 and = -177 × 10⁶/L, 95% CI: -323 to -30, p = 0.02, respectively). In contrast, we did not observe a difference in lymphocyte count between the lowest and highest quintiles of CnBP-3 in unadjusted or adjusted analyses.

Conclusion: We found an inverse relationship between BP-3 levels and WBC and neutrophil counts, and not with lymphocyte count. Further research is needed to confirm our findings.

Keywords: NHANES; benzophenone‐3; leukocytes; lymphocytes; neutrophils; organic UV filter; oxybenzone; sunscreen; sunscreen metabolite; white blood cells.